Author  
Place of duty  
Title   유방암 진행에 따른 Telomerase Activity 발현 증가 ( Increment of Telomerase Activity with Breast Cancer Progression )
Publicationinfo   1997 Jan; 029(06): 1032-1041.
Key_word   Breast cancer, Telomerase
Full-Text  
Abstract   Purpose: We studied the telomerase activity in normal and cancer tissues of the breast and then compared it to the clinical parameters. Materials and methods: 36 paired normal and cancerous breast tissues were assayed for telomerase activity by PCR-based TRAP assay(telomeric repeat amplification protocol). In 17 cancer tissues, flow cytometric analysis for S-phase fraction was done. Results: None of the normal breast tissue expressed telomerase activity while 23 out of 26 breast cancer tissue expressed telomerase activity(92%). Clinical parameters such as T-factor, tumor grade, hormone receptor expression, mitosis, S-phase fraction did not correlate with telomerase expression. However, telomerase acitvity increased with cancer progression such as; in a state of lymph node metastasis and in an advanced pathological stage. Conclusion: Telomerase activity was expressed only from cancer tissues. And this expression increased with cancer progression suggesting a possible therapeutic target in breast cancer.
저 자   박규현(Kyu Hyun Park),라선영(Seon Young Rah),김태수(Tae Soo Kim),이병찬(Byung Chan Lee),박세호(Se Ho Park),정현철(Hyun Chul Chung),이원영(Won Young Lee),김주항(Joo Hang Kim),노재경(Jae Kyung Roh),이경식(Kyung Sik Lee),민진식(Jin Sik Min),김병수(Byung Soo Kim),